Sleep Health Education Bonus Module: Melatonin – a Guide for Pediatric Providers
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References
Appleton RE, Jones AP, Gamble C, et al. (2012). The use of Melatonin in children with Neurodevelopmental Disorders and impaired Sleep: a randomized double-blind, placebo controlled, parallel study (MENDS). Health Technology Assessment.16(40): ISSN 1366-5278
Buckley AW, Hirtz D, Oskoui M, et al. (2020). Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder: Report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology. Neurology. 94(9): 392-404.
Chen, Y. C., Tain, Y. L., Sheen, J. M., & Huang, L. T. (2012). Melatonin utility in neonates and children. Journal of the Formosan Medical Association. 111(2), 57-66.
Claustrat, B., & Leston, J. (2015). Melatonin: Physiological effects in humans. Neurochirurgie, 61(2-3), 77-84.
Cohen, P. A., Avula, B., Wang, Y. H., Katragunta, K., & Khan, I. (2023). Quantity of melatonin and CBD in melatonin gummies sold in the US. JAMA, 329(16), 1401-1402.
Cortesi F, Gianotti F, Sebastiani T, et al. (2012). Controlled-release melatonin, singly and combined with cognitive behavioral therapy, for persistent insomnia in children with autism spectrum disorders: a randomized placebo-controlled trial. J Sleep Research; 21(6): 700-09
Cruz-Sanabria, F., Carmassi, C., Bruno, S., Bazzani, A., Carli, M., Scarselli, M., & Faraguna, U. (2023). Melatonin as a chronobiotic with sleep-promoting properties. Current Neuropharmacology, 21(4), 951.
Eckerberg B, Lowden A, Nagai R, Akerstedt T. (2012). Melatonin treatment effects on adolescent students’ sleep timing and sleepiness in a placebo-controlled crossover study. Chronobiol Int. 29(9):1239-48. doi: 10.3109/07420528.2012.719962.
Edemann-Callesen H, Andersen HK, Ussing A, Virring A, Jennum P, Debes NM, Laursen T, Baandrup L, Gade C, Dettmann J, Holm J, Krogh C, Birkefoss K, Tarp S, Händel MN. (2023). Use of melatonin in children and adolescents with idiopathic chronic insomnia: a systematic review, meta-analysis, and clinical recommendation. EClinicalMedicine. 6;61:102048. doi: 10.1016/j.eclinm.2023.102048.
Erland LAE and Saxena PK. (2017). Melatonin natural health products and supplements: presence of serotonin and significant variability of melatonin content. J Clin Sleep Med; 13(2): 275-81
Freeman, D. I. (2024). Notes from the Field: Emergency Department Visits for Unsupervised Pediatric Melatonin Ingestion—United States, 2019–2022. MMWR. Morbidity and Mortality Weekly Report, 73.
Gringras P, Gamble C, Wiggs L, et al. (2012). Melatonin for sleep problems in children with neurodevelopmental disorders: randomized double mask placebo-controlled trial. British Medical Journal. 345: e6664 doi 10.1136/bmj.
Gringras P, Nir T, Breddy J, et al. (2017). Efficacy and safety of pediatric prolonged-release melatonin for insomnia in children with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 56(11): 948-57
Handel MN, Andersen HK, Ussing A, et al. (2023). The short term and long term effects of melatonin treatment in children and adolescents: a systematic review and GRADE assessment. eClinical Medicine. 61: 102083
Hartstein, L. E., Garrison, M. M., Lewin, D., Boergers, J., & LeBourgeois, M. K. (2024). Characteristics of melatonin use among US children and adolescents. JAMA pediatrics, 178(1), 91-93.
Hartstein, L. E., Garrison, M. M., Lewin, D., Boergers, J., Hiraki, B. K., Harsh, J. R., & LeBourgeois, M. K. (2024). Factors contributing to US parents’ decisions to administer melatonin to children. Sleep Medicine, 114, 49-54.
Hayashi M, Mishima K, Fukumizu M, et al. (2022). Melatonin treatment and adequate sleep hygiene interventions in children with autism spectrum disorder: a randomized controlled trial. J Autism and Developmental Disorders. 5: 2784-93
International Classification of Sleep Disorders, third edition, text revision, American Academy of Sleep Disorders, 2023.
Kimland, E. E., Bardage, C., Collin, J., Järleborg, A., Ljung, R., & Iliadou, A. N. (2021). Pediatric use of prescribed melatonin in Sweden 2006–2017: a register based study. European Child & Adolescent Psychiatry, 30(9), 1339-1350.
Lee, S. K., Smith, L., Tan, E. C., Cairns, R., Grunstein, R., & Cheung, J. M. (2023). Melatonin use in children and adolescents: A scoping review of caregiver perspectives. Sleep Medicine Reviews, 101808.
Lelak, K. (2022). Pediatric Melatonin Ingestions—United States, 2012–2021. MMWR. Morbidity and Mortality Weekly Report, 71.
Lovegrove, M. C., Weidle, N. J., & Budnitz, D. S. (2015). Trends in emergency department visits for unsupervised pediatric medication exposures, 2004–2013. Pediatrics, 136(4), e821-e829.
Malow BA, Findling RL, Schroeder CM, et al. (2021). Sleep, growth and puberty after 2 years of prolonged release. Melatonin in children with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 60(2): 252-61
Maras A, Schroeder CM, Malow BA, et al. (2018). long-term efficacy and safety of pediatric prolonged-release melatonin for insomnia in chidren with autism spectrum disorder. J Child and Adolescent Psychopharmacology. 20: 1-12
Mombelli, S., Bacaro, V., Curati, S., Berra, F., Sforza, M., Castronovo, V.,Ferini-Strambi, L., Galbiati, A., & Baglioni, C. (2023). Non-pharmacological and melatonin interventions for pediatric sleep initiation and maintenance problems: A systematic review and network meta-analysis. Sleep Medicine Reviews. 101806.
Salanitro M, Wrigley T, Ghabra H, et al. (2022). Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: a systematic review and meta-analysis. Neuroscience and Behavior Research.139: 104723.
Schroder, C. M., Malow, B. A., Maras, A., Melmed, R. D., Findling, R. L., Breddy, J., … & Gringras, P. (2019). Pediatric prolonged-release melatonin for sleep in children with autism spectrum disorder: impact on child behavior and caregiver’s quality of life. Journal of Autism and Developmental Disorders, 49, 3218-3230.
Schroeder CM, Banaschewski T, Fuentes J, et al. (2021). Pediatric prolonged-release melatonin for insomnia in children and adolescents with autism spectrum disorder. Expert Opinion on Pharmacotherapy.18: 2445-454
Shenoy, P., Etcheverry, A., Ia, J., Witmans, M., & Tablizo, M. A. (2024). Melatonin use in pediatrics: a clinical review on indications, multisystem effects, and toxicity. Children, 11(3), 323.
Skrzelowski, M., Brookhaus, A., Shea, L. A., & Berlau, D. J. (2021). Melatonin use in pediatrics: evaluating the discrepancy in evidence based on country and regulations regarding production. The Journal of Pediatric Pharmacology and Therapeutics, 26(1), 4-20.
Smits, M. G., Nagtegaal, E. E., van der Heijden, J., Coenen, A. M., & Kerkhof, G. A. (2001). Melatonin for chronic sleep onset insomnia in children: a randomized placebo-controlled trial. Journal of Child Neurology, 16(2), 86-92.
Smits MG, van Stel HF, van der Heijden K, Meijer AM, Coenen AM, Kerkhof GA. (2003). Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial. Journal of the American Academy of Child & Adolescent Psychiatry, 42(11), 1286-1293.
van Maanen, A., Meijer, A. M., Smits, M. G., Van Der Heijden, K. B., & Oort, F. J. (2017). Effects of melatonin and bright light treatment in childhood chronic sleep onset insomnia with late melatonin onset: a randomized controlled study. Sleep, 40(2), zsw038.